![AffiAB® Anti-SHIP1 Purified [SHIP-01]](/web/image/product.product/79343/image_1024/%5BAFG-EXB-0373%5D%20AffiAB%C2%AE%20Anti-SHIP1%20Purified%20%5BSHIP-01%5D?unique=1da554d)
Overview
SHIP-1 (SH2 domain containing inositol phosphatase-1) is a 5´inositol phosphatase that regulates cell responses in lymphocytes and myeloid cells by hydrolyzing the second messenger PI (3, 4, 5) trisphosphate. SHIP-1 is recruited upon engagement of both inhibitory and activatory receptors, such as FcgammaRIIB, Fcgamma RIII, FcepsilonRI or cytokine and growth factor receptors, and supresses PI3K-dependent signaling, down-regulates cell migration and invasion of transformed cells and phagocytosis. SHIP-1 also serves as a scaffold for the recruitment of other proteins to the plasma membrane.
Specificity:
The antibody SHIP-01 reacts with SHIP-1, a phosphoinositide phosphatase largely confined to hematopoietic cells (intracellular antigen) . Multiple forms of SHIP-1 have been reported with molecular weights of 110, 125, 130, 135 and 145 kDa.
Antigen
SHIP1
Clone
SHIP-01
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG2a
Immunogen
Peptide coresponding to a sequence within N-terminal domain of human SHIP-1.
Application
FC (IC), WB
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide