AffiAB® Anti-ARAP1 Purified [ARAP1-2]

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CAT# AFG-EXB-0369
Size: 0.1 mg

239.00 239.0 USD 239.00

239.00

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Overview

ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeate. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.


Specificity:

The antibody ARAP1-2 reacts with C-terminal part of ARAP1 (intracellular epitope), a 160 kDa adaptor protein.

Antigen

ARAP1

Clone

ARAP1-2

Species Reactivity

Human

Negative Species

N/A

Isotype

Mouse IgG1

Immunogen

His6-tagged protein corresponding to amino acids 1190-1450 of human ARAP1

Application

IP, WB, ICC

Regulatory status

RUO

Concentration

1 mg/ml

Format

Purified

Storage / Stability

Store at 2-8°C. Do not freeze.

Storage Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide