![AffiAB® Anti-NTAL Purified [PAb (486) ]](/web/image/product.product/79319/image_1024/%5BAFG-EXB-0349%5D%20AffiAB%C2%AE%20Anti-NTAL%20Purified%20%5BPAb%20%28486%29%20%5D?unique=1da554d)
Overview
NTAL (non-T cell activation linker), also known as LAB (linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
Specificity:
The polyclonal antibody recognizes N-terminal cytoplasmic domain of mouse Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 25 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells.
Antigen
NTAL
Clone
PAb (486)
Species Reactivity
Mouse
Negative Species
Human
Isotype
Rabbit polyclonal
Immunogen
Recombinant N-terminal cytoplasmic domain (aa 124-203) of mouse NTAL.
Application
WB
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide