![AffiAB® Anti-HLA-DR1 (empty) Purified [MEM-267]](/web/image/product.product/79284/image_1024/%5BAFG-EXB-0314%5D%20AffiAB%C2%AE%20Anti-HLA-DR1%20%28empty%29%20Purified%20%5BMEM-267%5D?unique=1da554d)
Overview
HLA-DR1 belongs to the HLA class II beta chain paralogues. The MHC Class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. MHC Class II molecules are expressed in antigen presenting cells (APC) . The beta chain is approximately 26-28 kDa. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.
Specificity:
The antibody MEM-267 specifically binds extracellularly to the empty but not peptide-loaded form of HLA-DR1. DR is the isotypes of human MHC Class II molecules expressed on antigen-presenting cells (APC; dendritic cells, B lymphocytes, monocytes, macrophages) .
Antigen
HLA-DR1 (empty)
Clone
MEM-267
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG2b
Immunogen
Purified, insoluble DR1 beta chain (DRB1*0101) expressed in E. coli inclusion bodies.
Application
WB, FC, ELISA
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide