![AffiAB® Anti-Hu CD41a Purified [HIP8]](/web/image/product.product/79270/image_1024/%5BAFG-EXB-0300%5D%20AffiAB%C2%AE%20Anti-Hu%20CD41a%20Purified%20%5BHIP8%5D?unique=d31c23b)
Overview
CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.
Specificity:
The antibody HIP8 reacts with an extracellular epitope on alpha (a) subunit of CD41 (heavy chain; 120 kDa) . CD41 is mainly expressed on platelets and megakaryocytes. The antibody HIP8 blocks platelet aggregation and completely inhibits ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibits ristocetin- and thrombin-induced platelet activation. HIP8 is useful in the morphological and physiological studies o platelets and megakaryocytes.
Antigen
CD41a
Clone
HIP8
Species Reactivity
Non-human primates, Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
N/A
Application
FC (QC tested), IHC (F)
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide