![AffiAB® Anti-alpha-Fetoprotein Purified [AFP-11]](/web/image/product.product/79244/image_1024/%5BAFG-EXB-0274%5D%20AffiAB%C2%AE%20Anti-alpha-Fetoprotein%20Purified%20%5BAFP-11%5D?unique=1da554d)
Overview
Alpha-fetoprotein (AFP) is present in fetal plasma, and it binds e.g. copper, nickel, and bilirubin. Measuring of alpha-fetoprotein level in amniotic fluid can reveal severe fetal defects. In adults, elevated AFP concentrations in the plasma can indicate hepatocellular carcinoma or teratoblastoma. In some individuals, hereditary persistance of alpha-fetoprotein can be observed without any obvious pathology.
Specificity:
The mouse monoclonal antibody AFP-11 reacts with human alpha-Fetoprotein (AFP), a 70 kDa oncofetal antigen. AFP is a major fetal plasma protein, but is not present in healthy adult tissues. Elevated AFP concentrations in adult plasma may be an early marker of hepatocellular carcinoma or teratoblastoma, while high concentrations in amniotic fluid may indicate severe congenital defects of a fetus.
Antigen
alpha-Fetoprotein
Clone
AFP-11
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
purified alpha-Fetoprotein
Application
IHC (P), ELISA, RIA, WB
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide