AffiAB® Anti-CSK Purified [CSK-04]

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CAT# AFG-EXB-0269
Size: 0.1 mg

239.00 239.0 USD 239.00

239.00

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Overview

C-terminal Src kinase (Csk) is a non-receptor protein tyrosine kinase which resembles Src-family kinases, but unlike them it lacks the conserved autophosphorylation site, the regulatory C-terminal tyrosine as well as myristylation and palmitylation. Csk negatively regulates Src-family kinases by phosphorylation of their C-terminal regulatory tyrosine. Disruption of the csk gene causes constitutive activation of Src-family kinases, and overexpression of Csk usually counteracts their signaling. The Csk-mediated regulation of those Src-family kinases, that are localized in lipid rafts, is enabled by a ubiquitously expressed transmembrane adaptor PAG (also known as Cbp, Csk-binding protein), which recruits Csk.


Specificity:

The mouse monoclonal antibody CSK-04 reacts with Csk (C-terminal Src kinase), a 50 kDa intracellular non-receptor protein tyrosine kinase.

Antigen

CSK

Clone

CSK-04

Species Reactivity

Human, Mouse

Negative Species

N/A

Isotype

Mouse IgG1

Immunogen

Bacterially expressed recombinant fragment of human Csk corresponding to aa 330-450.

Application

WB, IP, ICC

Regulatory status

RUO

Concentration

N/A

Format

Purified

Storage / Stability

Store at 2-8°C. Do not freeze.

Storage Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide