![AffiAB® Anti-Hu CD42b Purified [HIP1]](/web/image/product.product/79228/image_1024/%5BAFG-EXB-0258%5D%20AffiAB%C2%AE%20Anti-Hu%20CD42b%20Purified%20%5BHIP1%5D?unique=d31c23b)
Overview
CD42b (GPIb alpha) composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.
Specificity:
The antibody HIP1 reacts with an extracellular epitope of CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa) ; CD42b/c forms a noncovalent complex with CD42a and CD42d.
Antigen
CD42b
Clone
HIP1
Species Reactivity
Non-human primates, Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Peripheral blood mononuclear cells of a patient suffering with CLL.
Application
FC (QC tested), IHC (F)
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide