![AffiAB® Anti-Bov CD41/CD61 Purified [IVA30]](/web/image/product.product/79218/image_1024/%5BAFG-EXB-0248%5D%20AffiAB%C2%AE%20Anti-Bov%20CD41-CD61%20Purified%20%5BIVA30%5D?unique=d31c23b)
Overview
CD41 (platelet glycoprotein IIb, integrin alpha IIb) is composed of two subunits (120 kDa transmembrane alpha chain and 23 kDa extracellular beta chain) and interacts with CD61 (platelet glycoprotein IIIa, integrin beta 3) in the presence of calcium to form a functional adhesive protein receptor. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin, and it is involved in platelet aggregation.
Specificity:
The antibody IVA30 reacts with an extracellular epitope on CD41/CD61 complex (bovine), one of the earliest markers of the megakaryocytic lineage. CD41/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor, vitronectin, thrombin and mediates platelets aggregation. CD41/CD61 is expressed only by platelets and megakaryocytes; the complex may be absent or strongly reduced in Glanzmann's thrombasthenia (GT) . This antibody crossreacts with human platelets.
Antigen
CD41/CD61
Clone
IVA30
Species Reactivity
Cow, Human
Negative Species
N/A
Isotype
Mouse IgG2
Immunogen
Bovine trombocytes.
Application
FC, IP, ICC, ELISA
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide