![AffiAB® Anti-HLA-DR Purified [HL-39]](/web/image/product.product/79132/image_1024/%5BAFG-EXB-0162%5D%20AffiAB%C2%AE%20Anti-HLA-DR%20Purified%20%5BHL-39%5D?unique=1da554d)
Overview
HLA-DR, a member of MHC class II glycoproteins, that bind intracellularly processed peptides and present them to the Th cells, is composed of 36 kDa alpha chain and 27 kDa beta chain, both anchored in the plasma membrane. Together with other MHC II molecules HLA-DR plays a central role in the immune system.
Specificity:
The antibody HL-39 recognizes an extracellular common epitope on human HLA-DR, which is dependent on the association of alpha and beta chains. Recognized epitope is conserved after fixation with glutaraldehyde and formaldehyde. DR is the isotype of human MHC Class II molecules expressed on antigen-presenting cells (APC; dendritic cells, B lymphocytes, monocytes, macrophages) .
Antigen
HLA-DR
Clone
HL-39
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG3
Immunogen
Raji Burkitt's lymphoma cell line
Application
FC (QC tested), IP
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide