![AffiAB® Anti-Hu CD57 Purified [TB01]](/web/image/product.product/79054/image_1024/%5BAFG-EXB-0084%5D%20AffiAB%C2%AE%20Anti-Hu%20CD57%20Purified%20%5BTB01%5D?unique=d31c23b)
Overview
CD57, also known as HNK1 or Leu7, is a sulphated trisaccharide (3-O-sulfoglucuronic acid beta1-3 Gal beta1-4 GlcNAc) attached to several glycoproteins, including CD56, myelin glycoprotein PO, and neural cell adhesion molecule L1, as well as on glycolipids and chondroitin sulphate proteoglycans in the nervous system. It serves as a NK cell marker and it is expressed on well differentiated prostate cancers and uveal and cutaneous melanoma. CD57+ T cells are implicated as suppressors of T-cell responses.
Specificity:
The mouse monoclonal antibody TB01 recognizes CD57, a carbohydrate extracellular antigen present mainly on NK cells, NK T cells, and in neural tissue.
Antigen
CD57
Clone
TB01
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgM
Immunogen
A pool of neuroblastoma cell lines
Application
FC (QC tested), WB, IHC (P), IHC (F), ICC
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide