![AffiAB® Anti-Hu CD170 Purified [1A5]](/web/image/product.product/79052/image_1024/%5BAFG-EXB-0082%5D%20AffiAB%C2%AE%20Anti-Hu%20CD170%20Purified%20%5B1A5%5D?unique=d31c23b)
Overview
CD170, also known as Siglec 5 (sialic acid binding Ig-like lectin 5) is a type 1 transmembrane glycoprotein containing two cytoplasmic immunoreceptor tyrosine inhibitory motifs (ITIMs) . CD170 forms homodimers and functions as an inhibitory receptor able to downregulate cell activation. It binds to alpha2, 3- and alpha2, 6-linked sialic acid ligands, e.g. on glycophorin A (CD235a) . Aberrant expression of CD170 by CD34+ progenitor cells can be observed in case of acute myeloid leukemias.
Specificity:
The mouse monoclonal antibody 1A5 recognizes an extracellular epitope of CD170 (Siglec-5, sialic acid binding Ig-like lectin 5), a transmembrane glycoprotein expressed strongly by neutrophils, macrophages activated during infections, monocytes, and dendritic cells. As in case with other anti-CD170 antibodies, this antibody crossreacts with Siglec-14, whose first two Ig domains are almost identical to those of CD170.
Antigen
CD170
Clone
1A5
Species Reactivity
Non-human primates, Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Fusion protein composed of human CD170 extracellular domain and Fc region of human IgG1
Application
FC (QC tested), IP, IHC (F), ICC, ELISA
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide