![AffiAB® Anti-Hu CD164 Purified [67D2]](/web/image/product.product/79032/image_1024/%5BAFG-EXB-0062%5D%20AffiAB%C2%AE%20Anti-Hu%20CD164%20Purified%20%5B67D2%5D?unique=d31c23b)
Overview
CD164, also known as endolyn, is a type I transmembrane protein with heavily glycosylated extracellular part containing sialic acid and glycosaminoglycan residues. CD164 plays both adhesive and antiadhesive role and serves as a potent negative regulator for CD34+ CD38- hematopoietic progenitor cell proliferation. It has also been reported to be involved in myogenic differentiation and cancer metastasis. The adhesive and negative regulatory functions seem to depend on different posttranslational modifications of CD164 protein.
Specificity:
The mouse monoclonal antibody 67D2 recognizes an extracellular class III epitope (not sensitive to sialidase, N-glycanase, O-glycosidase, and O-sialoglycoprotease) of CD164, a sialomucin expressed in hematopoietic myeloid and erythroid progenitors, activated basophils, and in various carcinomas and leukemic cells.
Antigen
CD164
Clone
67D2
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Breast tumor cell line T-47D
Application
FC (QC tested), IP, WB, ICC
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide