![AffiAB® Anti-Ms LPAM-1 Purified Azide Free [DATK32]](/web/image/product.product/79006/image_1024/%5BAFG-EXB-0034%5D%20AffiAB%C2%AE%20Anti-Ms%20LPAM-1%20Purified%20Azide%20Free%20%5BDATK32%5D?unique=1da554d)
Overview
Integrin alpha 4 / beta 7 (CD49d / Ly69) , also known as LPAM-1 (Llmphocyte Peyer´s patch adhesion molecule 1), is a heterodimeric (150 kDa / 130 kDa) integrin complex which mediates lymphocyte homing to Peyer´s patch high endothelial venules and to the intestinal lamina propria. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. Ligands of LPAM-1 are MAdCAM-1, VCAM-1, and fibronectin, but the alpha 4 subunit (CD49d) can mediate also homotypic adhesion.
Specificity:
The rat monoclonal antibody DATK32 recognizes an extracellular epitope of integrin alpha 4 (CD49d) and integrin beta7 (Ly69) components of mouse LPAM-1 complex, which is expressed on the majority of peripheral lymphocytes, as well as on subsets of thymocytes and bone marrow cells.
Antigen
LPAM-1
Clone
DATK32
Species Reactivity
Mouse
Negative Species
N/A
Isotype
Rat IgG2a kappa
Immunogen
TK1 cells
Application
FUNC, FC (QC tested), IP, IHC (F)
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified Azide Free
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4