![AffiAB® Anti-Hu CD34 Purified Azide Free [QBEnd-10]](/web/image/product.product/78994/image_1024/%5BAFG-EXB-0022%5D%20AffiAB%C2%AE%20Anti-Hu%20CD34%20Purified%20Azide%20Free%20%5BQBEnd-10%5D?unique=d31c23b)
Overview
CD34 is a highly glycosylated monomeric 111-115 kDa surface protein, which is present on many stem cell populations. It is a well established stem cell marker, though its expression on human hematopoietic stem cells is reversible. CD34 probably serves as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions.
Specificity:
The antibody QBEnd-10 reacts with an extracellular class II epitope on CD34, a 110-115 kDa monomeric transmembrane phosphoglycoprotein expressed on hematopoietic progenitors cells and on the most pluripotential stem cells; it is gradually lost on progenitor cells. This antibody has been also used as an endothelial marker.
Antigen
CD34
Clone
QBEnd-10
Species Reactivity
Non-human primates, Human
Negative Species
Dog, Sheep, Rat, Cow
Isotype
Mouse IgG1
Immunogen
Human endothelial vesicles
Application
FC (QC tested), IP, WB, IHC (P), IHC (F), FUNC
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified Azide Free
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4