![AffiAB® Anti-Hu CD11b Purified Azide Free [MEM-170]](/web/image/product.product/78989/image_1024/%5BAFG-EXB-0017%5D%20AffiAB%C2%AE%20Anti-Hu%20CD11b%20Purified%20Azide%20Free%20%5BMEM-170%5D?unique=d31c23b)
Overview
CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18) ; expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.
Specificity:
The antibody MEM-170 recognizes an extracellular epitope of CD11b antigen (Mac-1alpha), a 165-170 kDa transmembrane protein type 1 mainly expressed on monocytes, granulocytes and NK-cells. The antibody blocks (not completely) Mac-1-mediated neutrophil binding to fibrinogen.
Antigen
CD11b
Clone
MEM-170
Species Reactivity
Human
Negative Species
N/A
Isotype
Mouse IgG1
Immunogen
Human granulocytes
Application
FC (QC tested), FUNC
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified Azide Free
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4