![AffiAB® Anti-Hu CD59 Purified Azide Free [MEM-129]](/web/image/product.product/78985/image_1024/%5BAFG-EXB-0013%5D%20AffiAB%C2%AE%20Anti-Hu%20CD59%20Purified%20Azide%20Free%20%5BMEM-129%5D?unique=d31c23b)
Overview
CD59 (protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC) . It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.
Specificity:
The antibody MEM-129 reacts with CD59 (Protectin), a 18-20 kDa glycosylphosphatidylinositol (GPI) -anchored extracellular glycoprotein expressed on all hematopoietic cells; it is widely present on cells in all tissus.
Antigen
CD59
Clone
MEM-129
Species Reactivity
Pig, Human
Negative Species
N/A
Isotype
Mouse IgM
Immunogen
Human peripheral blood lymphocytes
Application
FC (QC tested), FUNC
Regulatory status
RUO
Concentration
1 mg/ml
Format
Purified Azide Free
Storage / Stability
Store at 2-8°C. Do not freeze.
Storage Buffer
HEPES buffered saline (HBS), pH 7.0