Available Sizes: 25 μg, 100 μg.
Background
CD22 is a 130 kD type I transmembrane glycoprotein also known as Siglec-2 and BL-CAM. It is a member of the immunoglobulin superfamily (sialoadhesion subgroup). CD22 is expressed in the cytoplasm of pro-B and pre-B cells and on the surface of mature B and activated B cells, but not on plasma cells. CD22 is present in the B cell receptor complex and associates with SHP-1, Syk, Lck, Lyn and phospholipase Cγ1. A primary function of CD22 is thought to be in limiting Antigen receptor signaling by modulating B cell activation threshold. CD22 has been shown to bind to CD45RO and CD75, although the natural ligands for this molecule remain controversial.
Host
Mouse.
Species Reactivity
Human.
Synonyms
B-cell receptor CD22, Cd22, B-lymphocyte cell adhesion molecule, BL-CAM, Sialic acid-binding Ig-like lectin 2, Siglec-2, T-cell surface Antigen Leu-14, CD22, Lyb-8, Siglec2.
Conjugation
Unconjugated.
Isotype
N/A.
Applications
FCM.
Concentration
0.2 mg/mL.
Buffer
PBS with 0. 05% Proclin300.
Storage Conditions
Store at 2~8℃. Do not freeze.
Gene-ID
N/A.