Available Sizes: 25μg, 50 μg, 100 μg, 200 μg.
Background
CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α (CD8a) /β (CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes and lymphoid dendritic cells. CD8 is an Antigen co-receptor on T cells that interacts with MHC class I on Antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.
Host
Rat.
Species Reactivity
Mouse.
Synonyms
T-cell surface glycoprotein CD8 alpha chain, CD8A, T-lymphocyte differentiation Antigen T8/Leu-2, MAL.
Conjugation
PerCP/Cyanine5.5.
Isotype
Rat IgG2a, κ.
Applications
FCM.
Concentration
0.2 mg/mL.
Buffer
PBS with 0. 05% Proclin300, 1% BSA.
Storage Conditions
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Gene-ID
12525.