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Background
CD16 is known as low affinity IgG receptor III (FcγRIII). It is expressed as two distinct forms (CD16a and CD16b). CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. It is expressed on the surface of NK cells, activated monocytes, macrophages and placental trophoblasts in humans. CD16b (FcγRIIIB) is a 48 kD glycosylphosphatidylinositol (GPI) -anchored protein. Its extracellular domain is over 95% homologous to that of CD16a and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-Antigen complex which functions in NK cell activation, phagocytosis and Antibody-dependent cell-mediated cytotoxicity (ADCC).
Host
Mouse.
Species Reactivity
Human.
Synonyms
Low affinity immunoglobulin gamma Fc region receptor III-A, FCGR3A, CD16a Antigen, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2, CD16a.
Conjugation
PerCP/Cyanine5.5.
Isotype
Mouse IgG1, κ.
Applications
FCM.
Concentration
N/A.
Buffer
PBS with 0. 05% Proclin300, 1% BSA.
Storage Conditions
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Gene-ID
2214.