Available Sizes: 20 Tests, 50 Tests, 100 Tests, 200 Tests.
Background
CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts and at low levels on plasma cells. CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching and protection of B cells from apoptosis. Additionally, CD40 is important for T cell-B cell interactions. The ligand of CD40 is CD154 (CD40 ligand). The 5C3 Antibody has been reported to promote B cell proliferation in the presence of Anti-IgM, IL-4 or PMA, partially blocking CD40 binding to CD40L and B cells rescue from apoptosis.
Host
Mouse.
Species Reactivity
Human.
Synonyms
Tumor necrosis factor receptor superfamily member 5, Cd40, B-cell surface Antigen CD40, Bp50, CD40L receptor, CD40, Tnfrsf5.
Conjugation
PerCP.
Isotype
Mouse IgG2a, κ.
Applications
FCM.
Concentration
N/A.
Buffer
PBS with 0. 05% Proclin300, 1% BSA.
Storage Conditions
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Gene-ID
958.