Available Sizes: 20 Tests, 50 Tests, 100 Tests, 200 Tests.
Background
CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.
Host
Rat.
Species Reactivity
Mouse.
Synonyms
Integrin alpha-E, Itgae, Integrin alpha M290, CD103.
Conjugation
PE/Cyanine7.
Isotype
Rat IgG2a, κ.
Applications
FCM.
Concentration
N/A.
Buffer
PBS with 0. 05% Proclin300, 1% BSA.
Storage Conditions
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Gene-ID
16407.