AffiAB® PE/Cyanine5.5 Anti-Human CD57 Antibody

Background

CD57, also known as HNK-1, NK-1 and Leu-7 is a 100-115 kD oligosaccharide Antigenic determinant expressed on a variety of proteins, lipids and chondroitin sulfate proteoglycans. CD57 is expressed on a subset of peripheral blood lymphocytes, including NK cells and CD8+ T cells and is also expressed on neural cells and striated muscle. CD57 is not expressed on red blood cells, granulocytes, monocytes, or platelets. While the function of CD57 is unknown, binding to L-selectin, P-selectin and a fragment of laminin suggests that CD57 may be involved in cell-matrix interactions. CD57 is increased in some disease states associated with CD4/CD8 imbalances (AIDS, autoimmune disease, viral infections and allograft transplants).