Available Sizes: 20 Tests, 50 Tests, 100 Tests, 200 Tests.
Background
Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells and inhibitory effects on the Antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation, suppresses Foxp3 expression and serves as a target for treating inflammatory diseases.
Host
Mouse.
Species Reactivity
Human.
Synonyms
Interleukin-21, IL-21, Za11.
Conjugation
PE.
Isotype
Mouse IgG1, κ.
Applications
ICFCM.
Concentration
N/A.
Buffer
PBS with 0. 05% Proclin300, 1% BSA.
Storage Conditions
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Gene-ID
59067.