Available Sizes: 20 Tests, 50 Tests, 100 Tests.
Background
CD45 is a 180 - 240 kD single chain type I membrane glycoprotein also known as leukocyte common Antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes or platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle and oncogenic transformation. CD45 plays a critical role in T and B cell Antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface Antigens including CD1, CD2, CD3 and CD4.
Host
Mouse.
Species Reactivity
Human.
Synonyms
Receptor-type tyrosine-protein phosphatase C, Ptprc, L-CA, Ly-5, T200, CD45.
Conjugation
PE/Cyanine5.
Isotype
N/A.
Applications
FCM.
Concentration
N/A.
Buffer
PBS with 0. 05% Proclin300, 1% BSA.
Storage Conditions
Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze.
Gene-ID
N/A.