Available Sizes: 50 μg, 500 μg, 1 mg.
Background
CD8a is a 32 kD glycoprotein also known as T8, Lyt2, Ly-2 and CD8α. CD8a is a member of the immunoglobulin superfamily expressed on most thymocytes, subset of mature T cells, most NK cells, macrophages and some activated CD4+ T cells (not resting). CD8a forms heterodimers with the CD8β chain (CD8b) on the surface of most thymocytes, while mature peripheral T lymphocytes express almost exclusively the CD8 αβ heterodimer. Intestinal intraepithelial lymphocytes express CD8a without CD8b. CD8 is an Antigen co-receptor on T cells that interacts with MHC class I on Antigen-presenting cells or epithelial cells. CD8 participates in T cell activation through its association with the T cell receptor complex and protein tyrosine kinase lck (p56lck).
Host
Mouse.
Species Reactivity
Rat.
Synonyms
T-cell surface glycoprotein CD8 alpha chain, CD8A, T-lymphocyte differentiation Antigen T8/Leu-2, MAL.
Conjugation
None (Purified Antibody, Azide Free/Low endotoxin).
Isotype
N/A.
Applications
FCM, Wb, IHC, IP.
Concentration
0.2 mg/mL.
Buffer
0.2 μm filtered in PBS, pH7. 2. Azide Free (AF) /Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is less than 2 EU/mg ( less than 0. 002EU/μg) as Determined by LAL gel clotting assay.
Storage Conditions
Store at 2~8℃. Do not freeze.
Gene-ID
N/A.