Available Sizes: 50 μg, 500 μg, 1 mg.
Background
CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α (CD8a) /β (CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes and lymphoid dendritic cells. CD8 is an Antigen co-receptor on T cells that interacts with MHC class I on Antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.
Host
Rat.
Species Reactivity
Mouse.
Synonyms
T-cell surface glycoprotein CD8 alpha chain, CD8A, T-lymphocyte differentiation Antigen T8/Leu-2, MAL.
Conjugation
None (Purified Antibody-Azide Free/Low endotoxin).
Isotype
Rat IgG2a, κ.
Applications
Block, Depletion, FCM.
Concentration
0.5 mg/mL.
Buffer
0.2 μm filtered in PBS, pH7. 2. Azide Free (AF) /Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is less than 2 EU/mg as Determined by LAL gel clotting assay.
Storage Conditions
Store at 2~8°C. Do not freeze.
Gene-ID
12525.