Available Sizes: 50 μg, 500 μg, 1 mg.
Background
CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 Antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.
Host
Rat.
Species Reactivity
Mouse.
Synonyms
Interleukin-2 receptor subunit beta, Il2rb, IL-2 receptor subunit beta,
IL-2R subunit beta, IL-2RB, High affinity IL-2 receptor subunit beta, p70-75, CD122.
Conjugation
None (Purified Antibody-Azide Free/Low endotoxin).
Isotype
Rat IgG2a, κ.
Applications
FCM.
Concentration
0.5 mg/mL.
Buffer
0.2 μm filtered in PBS, pH7. 2. Azide Free (AF) /Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is less than 2 EU/mg as Determined by LAL gel clotting assay.
Storage Conditions
Store at 2~8°C. Do not freeze.
Gene-ID
16185.