Available Sizes: 50 μg, 500 μg, 1 mg.
Background
CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on Antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation.
Host
Mouse.
Species Reactivity
Human.
Synonyms
PAS2, MNS, HGpMiX, GYPA, GPSAT.
Conjugation
None (Purified Antibody-Azide Free/Low endotoxin).
Isotype
Mouse IgG1, κ.
Applications
Activation, FCM.
Concentration
0.5 mg/mL.
Buffer
0.2 μm filtered in PBS, pH7. 2. Azide Free (AF) /Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is less than 2 EU/mg as Determined by LAL gel clotting assay.
Storage Conditions
Store at 2~8°C. Do not freeze.
Gene-ID
940.