Overview
CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular scavenger receptor cysteine-rich (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.
Conjugate
CF647.
Concentration
0.1 mg/mL.
Storage Buffer
PBS, 0.1% BSA, 0.05% azide.
Product Applications
Flow (verified) |Flow, surface (published) |Functional studies (published) |IF (published) |IF (verified) .
Storage Temperature
2°C to 8°C.
Stability
Stable at room temperature or 37°C (98°F) for 7 days.