Welcome to AffiAB®
Pioneering Antibodies for Precision Research.
At AffiGEN, we proudly introduce our esteemed brand, AffiAB® – your gateway to a world of precision antibodies meticulously crafted for the most demanding research endeavors. Rooted in scientific innovation and unwavering quality, AffiAB® has been engineered to empower researchers, scientists, and laboratories with a cutting-edge suite of antibodies.
Why Choose AffiAB® Antibodies?
Our antibodies are developed using rigorous quality
control measures to ensure consistent and reliable
performance. Each product undergoes thorough testing to
deliver superior specificity and sensitivity.
Broad Range of Targets
Explore our vast selection of antibodies targeting various
proteins, receptors, and biomarkers across diverse
research areas. From cancer research to immunology,
neuroscience to cell biology, we have antibodies tailored
to your specific needs.
Our antibodies undergo extensive validation procedures,
including various applications such as Western blotting,
immunohistochemistry, flow cytometry, and more. We provide
detailed validation data to assist you in choosing the
right antibody for your experiments.
Custom Antibody Services
In addition to our catalog antibodies, we offer custom
antibody development services to meet your unique research
requirements. Our experienced team can collaborate with
you to generate highly specific antibodies tailored to
your specific targets.
We are dedicated to providing exceptional customer
support. Our knowledgeable team of scientists is ready to
assist you with any inquiries, technical support, or
guidance you may need in selecting and using our
We are dedicated to providing exceptional customer
satisfaction. We believe in building long-lasting
relationships with our customers based on trust,
reliability, and excellent service. Our knowledgeable team
of scientists is readily available to assist you with any
inquiries, technical support, or guidance related to our
antibodies. Your success is our priority.
DBR1 (Debranching RNA Lariats 1 Homolog) Antibody
The DBR1 enzyme is responsible for the debranching of RNA lariats. In the splicing of pre-messenger RNA (pre-mRNA), introns are removed, leaving lariat structures. DBR1 plays a crucial role in the resolution of these lariats by removing the 2'-5' phosphodiester linkage at the branchpoint.
Proper mRNA splicing is essential for the production of functional, mature mRNA molecules that can be translated into proteins. Dysregulation of RNA processing can have significant impacts on cellular function and is associated with various diseases.
Research on the DBR1 gene and its enzyme is often conducted to understand the molecular mechanisms of RNA processing, splicing, and their implications for cellular function. This knowledge can have implications for various fields, including molecular biology, genetics, and potentially therapeutic development.
MYF6 (Myogenic Factor 6) Antibody
MYF6 is a transcription factor that regulates the expression of genes involved in muscle development and differentiation. It plays a role in the determination of the myogenic lineage and the formation of skeletal muscle.
MYF6 is expressed during embryonic development and is involved in the formation of skeletal muscle tissue. It continues to be expressed in adult muscle tissues, contributing to muscle maintenance and regeneration.
Myogenesis is the process by which muscle tissue is formed during embryonic development and in certain regenerative processes in adults. MYF6, along with other MRFs, helps orchestrate the differentiation of myoblasts (precursor cells) into mature muscle fibers.
Mutations or dysregulation of MYF6 can be associated with certain muscle-related disorders or abnormalities in muscle development. Research on MYF6 and related genes is ongoing to understand their roles in normal muscle physiology and pathogenesis.
CLTA (Clathrin Light Chain A) Antibody
Clathrin is a protein that assembles into a lattice structure to form coated pits on the cell membrane. The clathrin light chain A is one of the components of the clathrin triskelion, contributing to the stability and function of the clathrin-coated vesicles.
Clathrin-mediated endocytosis is a process by which cells take in molecules from the external environment. Clathrin-coated vesicles are responsible for transporting various molecules, including receptors, from the cell surface to the interior, allowing for processes like nutrient uptake and receptor recycling.
The clathrin-mediated endocytosis pathway is crucial for maintaining cell homeostasis, signal transduction, and the regulation of membrane protein composition.
Understanding the molecular mechanisms of clathrin and its associated proteins, including CLTA, is essential for unraveling the complexities of cellular trafficking and signaling.
COL11A1 (Collagen Type XI Alpha 1
The COL11A1 gene produces the alpha-1 chain of type XI collagen, which, along with alpha-2 chains (encoded by COL11A2), forms a heterotrimeric molecule.
Type XI collagen is typically found in cartilage, intervertebral disc, vitreous humor of the eye, and other connective tissues. It contributes to the structural integrity of these tissues.
Collagens are crucial for the strength, elasticity, and structure of various tissues. Type XI collagen, in particular, is involved in maintaining the integrity of cartilage and other connective tissues.
Mutations or dysregulation of the COL11A1 gene can be associated
with certain genetic disorders or conditions affecting the
skeletal system and connective tissues. For example, mutations
in COL11A1 have been linked to Stickler syndrome, a genetic
disorder characterized by joint problems, facial abnormalities,
and hearing loss.
TOP3A (DNA Topoisomerase 3-alpha) Antibody
DNA topoisomerases are enzymes that regulate the topological structure of DNA by introducing temporary breaks in the DNA strands. TOP3A specifically is a type I topoisomerase, and it is involved in the relaxation of supercoiled DNA. This enzyme can also play a role in DNA repair and recombination.
The proper functioning of DNA topoisomerases is critical for various cellular processes, including DNA replication, transcription, and chromatin structure maintenance. By modulating DNA topology, these enzymes contribute to the prevention of excessive DNA supercoiling and facilitate essential cellular activities.
TOP3A is implicated in DNA replication and repair, where it helps resolve DNA entanglements and ensures the accurate maintenance of genetic information.
Understanding the role of TOP3A in cellular processes is essential for advancing our knowledge of DNA dynamics and the molecular mechanisms involved in maintaining genome stability.
Dysregulation or mutations in genes encoding DNA topoisomerases,
including TOP3A, can be associated with various genetic
disorders and cancers. Research on these enzymes has
implications for cancer biology and potential therapeutic